Explain Negishi coupling reaction with an example and give its mechanism.

Discuss the disconnections for the synthesis of benzocaine.

Explain the synthesis of azepine using ethoxycarbonyl nitrene.

Draw the taustomeric forms of azepines and compare their stabilities.

Discuss the Skraup synthesis of quinoline giving the reactions involved.

How can benzotriazole be synthesised starting from ortho-phenylenediamine? Give the mechanism of the reaction.

Discuss Bischer synthesis of indole. How can you obtain a single product in this reaction?  

 Illustrate giving two [3+2] cycloaddition reactions how can 1,3-dipolar compounds react with alkenes and alkynes to give pyrazoles.

Give the products of the reaction of azetedine with the following reagents:

(i) RCOCI

(ii) CS2

(iii) HNO2

(iv) HCHO

(v)HCI/A

 Discuss how can tetraalkylaziridines be synthesised.

 Explain the chemical shift values exhibited in the 'H-NMR spectrum of pyridine.

Pyrazine

 Pyridazine

 2,5-Diazaanthracene

 2-Methylazacyclohexane

Pyrazino [2, 3,-c] pyridazine

Write the names of the following compounds according to Hantzsch-Widman system of nomenclature.

 Explain the natural drivers of climate change.

 Explain the sources of palaeoclimatic data.

General Circulation Models