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When a solute is distributed between two immiscible phases, usually an aqueous phase and an organic phase, two related but distinct terms are used to describe its distribution: distribution coefficient and distribution ratio. The distribution coefficient, generally denoted as K or KD, refers to the ratio of the concentrations of a solute in the two phases considering only a single, well-defined chemical species of the solute. It is applicable when the solute exists in the same ___ _______ ________ ______ __________ ____ ______ __________ ______ ____ ____ _________.
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