Why is the defective allele for sickle cell hemoglobin (HbS) not eliminated from human population by natural selection?

The persistence of the defective allele for sickle cell hemoglobin (HbS) in the human population despite its detrimental effects is explained by a phenomenon known as heterozygote advantage, specifically in the context of malaria-endemic regions. The HbS allele causes sickle cell anemia when present in ______ ____ __________ __________ _______.
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