What is the role of calcium ion as a second messenger?

Calcium ion (Ca(2+)) plays an important role in stimulus-response reactions of cells as a second messenger. This is done by keeping cytoplasmic Ca(2+) concentration low at rest and by mobilizing Ca(2+) in response to stimulus, which in turn activates the cellular reaction. The _______ __________ _________ ______ __________ ____ _________ ____ ______ ___ ________.
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