What is peptide sequencing? Discuss with schematic representation, Edman degradation method of peptide sequencing. Mention its advantages and disadvantages.

Peptide sequencing refers to the process of determining the amino acid sequence of a peptide, which is a short chain of amino acids linked by peptide bonds. This process is critical in understanding the structure and function of proteins, as the sequence of amino acids in a peptide determines its properties and biological activity. Peptide sequencing is an essential tool in genomics and proteomics, helping to elucidate protein functions, understand diseases, and develop targeted therapeutics.

Edman Degradation Method

One of the classical methods for peptide sequencing is the Edman degradation technique, developed by Pehr Edman in 1950. This method sequentially removes one residue at a time from the amino terminus of a peptide, allowing the identification of each amino acid in the sequence. 

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