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Osteoporosis is a metabolic bone disorder characterized by decreased bone mass and deterioration of bone microarchitecture, leading to increased fragility and susceptibility to fractures. It occurs when bone resorption by osteoclasts exceeds bone formation by osteoblasts, resulting in porous and weakened bones. Biochemically, osteoporosis involves an imbalance in calcium and phosphate metabolism, often linked to alterations in ____ _________ _____ ______ __________.
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