What is Cell Mediated Immune System (CMIS)? Briefly describe the mode of action of CMIS

Cell-mediated immunity (CMI) is an immune response that does not involve antibodies but rather involves the activation of macrophages and NK-cells, the production of antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen . Cellular immunity protects the body by:

• Activating antigen-specific cytotoxic T-lymphocytes (CTLs) that are able to destroy body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
• Activating macrophages and NK cells, enabling them to destroy intracellular pathogens; and
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