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Structure–Activity Relationship (SAR) is a fundamental concept in pharmaceutical sciences that deals with the relationship between the chemical structure of a molecule and its biological activity. It studies how changes in the molecular structure of a drug candidate, such as alterations in functional groups, stereochemistry, or substituents, influence its pharmacological activity, potency, selectivity, and toxicity. Regulatory authorities place high emphasis on ______ _______ ________ __________ __________ _____.
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