Various symptoms of sickle cell anaemia

Sickle cell anemia is a genetic blood disorder that results in the production of abnormal hemoglobin, known as hemoglobin S. This abnormal hemoglobin causes red blood cells to become rigid and shaped like a crescent or "sickle" rather than the typical round shape. These sickle-shaped cells are less flexible and can block blood flow in small blood vessels, leading _______ _____ ____ _________ _____ _________ ____ _______.
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