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Transdermal drug delivery refers to the administration of therapeutic agents through the skin to achieve systemic effects. It is an advanced route of drug delivery that bypasses the gastrointestinal tract and first-pass metabolism in the liver, enhancing bioavailability and providing more consistent plasma drug levels. The skin, particularly the stratum ______ ____ __________ ____ ______ _______ __________ ________ ______ ___ ________.
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