Word Count : 252

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Calcium ions (Ca²⁺) play a central role in the regulation of muscle contraction in both skeletal and cardiac muscles. Muscle contraction is initiated when an action potential travels along the sarcolemma and into the transverse (T) tubules, triggering the release of Ca²⁺ from the sarcoplasmic reticulum (SR) into the cytosol. The increase in cytosolic Ca²⁺ concentration is the key signal that links electrical _____ ____ __________ ______ ________ ____ _____ ________ __________ _____.
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