Prosthetic Group

A prosthetic group is a non-polypeptide unit that is tightly and permanently attached to an enzyme and is crucial for its activity. Unlike cofactors that bind loosely and may be removed without affecting the enzyme structure, prosthetic groups are integral to the enzyme's function and cannot be easily separated. They are often involved in the enzyme's active _______ ______ _________ ______ _________ ______ __________.
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