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The three main processes of dealkylation in the microsomal metabolism of pesticides are O-dealkylation, N-dealkylation, and S-dealkylation. These processes occur primarily in the microsomal fraction of insect cells, involving enzymes such as cytochrome P450 monooxygenases. Dealkylation refers to the removal of alkyl groups (such as methyl, ethyl) from heteroatoms like oxygen, nitrogen, or sulfur within the pesticide molecule. These reactions play a critical role in detoxifying pesticides, modifying their chemical structure to reduce toxicity or facilitate excretion. O-dealkylation involves the removal of an alkyl group attached to an oxygen atom. This process typically converts an ether or ester functional group into a hydroxyl group and a corresponding aldehyde _________ _______ ___ ____ ___.
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