How is the enzyme, pyruvate dehydrogenase complex different from other enzymes? How does it function in the conversion of pyruvate to acetyl-CoA?

The pyruvate dehydrogenase complex (PDC) is a unique multi-enzyme system that differs significantly from most other enzymes in terms of structure and function. Unlike typical enzymes that function as single polypeptides or simple oligomers, PDC is a massive multi-subunit complex composed of three distinct enzyme components: pyruvate dehydrogenase (E1), dihydrolipoamide transacetylase (E2), and dihydrolipoamide dehydrogenase (E3). These enzymes work ____ ________ _______ ______ ______ _______ ______ _________ __________ ____.
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