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Fatty acid synthesis in animals is primarily regulated by covalent modification of key enzymes, especially acetyl-CoA carboxylase (ACC), which is the rate-limiting enzyme of the pathway. Covalent modification mainly occurs through reversible phosphorylation and dephosphorylation, allowing the cell to __________ ____ __________ __________ _____ _________ ____ __________ ___ ____ __________ _______.
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