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Metals, though essential in trace amounts for biological functions, can produce severe toxic effects when present in excess or in non-essential forms. Toxicity arises due to their strong affinity for biological ligands such as proteins, enzymes, and nucleic acids, leading to disruption of normal metabolic processes. Heavy metals are particularly hazardous because they are non-biodegradable and tend to accumulate in living organisms. Lead is __________ ___ ________ _____ _____ ________ ____ ___ ____ ________.
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