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Flip-flop refers to the transbilayer movement of lipid molecules from one leaflet of a biological membrane to the other. In a lipid bilayer, phospholipids are arranged asymmetrically, with distinct lipid compositions on the outer and inner leaflets, which is essential for membrane structure, function, and cell signaling. The spontaneous flip-flop of ________ ______ _________ __________ ______.
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