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In mammals, CFU-M and CFU-L represent committed hematopoietic progenitor cells derived from multipotent hematopoietic stem cells located mainly in the bone marrow. These stem cells arise during embryonic development from mesodermal tissue, initially appearing in the yolk sac and later colonizing the fetal liver, spleen, and finally the bone marrow, where definitive hematopoiesis is established and maintained throughout adult life. CFU-M, or colony-forming unit–monocyte, is a myeloid progenitor cell committed to the monocyte–macrophage lineage. Under the influence of specific growth factors such as macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating ___ ______ _____ _____ ________ ______ ____ ______ _______ ______ __________.
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