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Trisomy 21, commonly known as Down's Syndrome, is a chromosomal disorder characterized by the presence of an extra copy of chromosome 21 in the human genome. Normally, humans have 46 chromosomes arranged in 23 pairs, but in Trisomy 21, there are three copies of chromosome 21 instead of the usual two. This additional genetic material disrupts normal development and leads to a combination of physical, cognitive, and medical features. The primary cause of Trisomy 21 is nondisjunction during meiosis, where chromosome ___ ___ ____ ____ _____ ______ __________ _____ ________.
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