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Erythropoiesis is the process by which red blood cells (RBCs) are produced in the bone marrow to maintain adequate oxygen-carrying capacity of the blood. It begins with multipotent hematopoietic stem cells, which differentiate into erythroid progenitor cells under the influence of growth factors. The primary regulator of erythropoiesis is erythropoietin (EPO), a glycoprotein hormone secreted mainly by the _____ ____ ______ ____ _________ ___ _______.
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