Explain ẞ-oxidation pathway of saturated fatty acid breakdown.

Question

06 Jan 2025

Answer :

Word Count : 479

Beta-oxidation is the metabolic pathway through which fatty acids are broken down to generate acetyl-CoA, which can then enter the citric acid cycle (Krebs cycle) to produce ATP. This process primarily occurs in the mitochondria of cells.

The breakdown of a saturated fatty acid (such as palmitate) involves a series of four enzymatic steps. Here's a detailed breakdown of each step:

1. Activation: Before beta-oxidation can begin, the fatty acid is activated in the cytoplasm by attaching it to Coenzyme A (CoA), forming fatty acyl-CoA. This activation requires the input of ATP and is catalyzed __________ __________ ______ _____ ___ ___ _________ ____ __________.
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