Elucidate the symptoms of major depressive disorder. Explain the biological causal factors of unipolar mood disorder.

Major Depressive Disorder (MDD), commonly known as unipolar depression, is a mental health condition characterized by persistent feelings of sadness and a lack of interest or pleasure in daily activities. This disorder affects various aspects of a person's emotional, physical, and cognitive functioning. The symptoms of MDD can vary in severity but are typically present for at least two weeks and interfere significantly with daily life.

The core symptoms of MDD include:

1. Depressed mood: The individual experiences persistent sadness, hopelessness, or a general sense of emptiness. This mood often lasts throughout the day and occurs nearly every day.
  
2. Anhedonia: This refers to the inability to experience pleasure in activities that were once enjoyable, such as socializing, hobbies, or eating.

3. Changes in appetite or weight: Some individuals may experience significant weight ___ __________ _____ _______ __________ ______ ____ ______ __________ _______ ____.
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