Discuss the preparation of the following compounds starting from ethyl 3-
oxobutanoate?
i) 2-Butenoic acid (crotonic acid)
ii) 4-ketopentanoic acid
Preparation of 2-Butenoic Acid (Crotonic Acid) and 4-Ketopentanoic Acid from Ethyl 3-Oxobutanoate
i) 2-Butenoic Acid (Crotonic Acid):
To synthesize 2-Butenoic acid from ethyl 3-oxobutanoate, a Claisen condensation reaction followed by decarboxylation can be employed. The general reaction scheme is as follows:
1. Claisen Condensation: Ethyl 3-oxobutanoate undergoes Claisen condensation with itself in the presence of a base such as sodium ethoxide ____ ______ ______ _________ __________ ___ _______ ____.
____ __________ _______ __________ _____ _________ __________ __________ ____ _________ ________ ___.
_________ _____ _____ ___ ____ ______.
___ ___ ___ ___ ________ ________ _________ __________ ______.
____ ___ ______ _________ ________ ___ _______ _______.
________ ____ ______ _________ __________ _____ __________ ________ _____ __________ ________.
_______ _________ _____ ___ _____ _____ ______ _____ ____ ______ ___.
____ _____ ___ ____ _______ _______ ________ ____ ____ ________.
__________ ___ ___ __________ _____ ________ ____ __________ __________ ______ _____.
___ _______ ___ _______ ________.
________ __________ ________ ________ _____.
______ _______ _________ ________ ____ _______ ____ ______ ____ _________.
___ ________ _____ __________ ___ ______ __________ ___.
____ _______ _____ ____ ____ _________ ___.
____ _______ __________ ___ ______ ______.
___ _____ ___ ________ ___ __________ ______ ________ ___ _________ ___ ______.
____ ________ ___ ____ _____ ______.
______ ____ _______ ____ _______ __________ ________ ______.
_______ _____ _____ _____ _________ __________ __________ _____ _____ ______.
_______ ______ _____ ____ __________ _____ _________ _______.
____ ___ ____ __________ __________ _________ __________ ______ ___ _______ __________ ___.
_______ ____ _______ _________ _____ ________.
Get Full Answer on WhatsApp