Discuss the mechanism of Fischer esterification of carboxylic acids
Fischer esterification is a widely used organic reaction that converts a carboxylic acid and an alcohol into an ester, involving the formation of a new carbon-oxygen single bond. The mechanism of this reaction can be broken down into several key steps:
1. Protonation of the Carboxylic Acid: The reaction begins with the protonation of the carboxylic acid (RCOOH) by a strong acid, typically sulfuric acid (H2SO4). This step increases the electrophilicity ___ ____ ____ __________ ______ __________.
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