Question

Discuss alternate pathway of complement activation.

23 Jan 2025
Answer :
Word Count : 526

The alternate pathway of complement activation plays a crucial role in the innate immune response, providing a rapid defense mechanism against pathogens. Unlike the classical pathway, which requires the binding of antibodies to antigens, the alternate pathway is antibody-independent and is constantly activated at low levels in the circulation. This pathway amplifies the immune response and acts as a first line of defense, recognizing a broad range of pathogens, including bacteria, viruses, fungi, and parasites.

The alternate pathway is initiated by spontaneous hydrolysis of the complement component ____ ________ __________ ____ __________ __________.
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