Word Count : 239

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The conversion of pyruvate into acetyl Co-A is a crucial step in cellular respiration that takes place in the mitochondria and is catalyzed by the pyruvate dehydrogenase complex (PDC). This multienzyme complex is composed of three major enzymes: pyruvate dehydrogenase (E1), dihydrolipoamide transacetylase (E2), and dihydrolipoamide dehydrogenase (E3). The phenomenon of substrate channeling is a distinctive feature of this ____ _________ ____ ___ ________ ____ ___.
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