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Physiological ions play a vital role in maintaining cellular functions, nerve transmission, muscle contraction, and overall homeostasis of the human body. In the context of drugs regulatory affairs, understanding these ions is important for assessing drug safety, efficacy, and possible electrolyte imbalances caused by therapeutic agents. Sodium (Na⁺) is the major extracellular cation responsible for maintaining fluid balance, osmotic pressure, and nerve ____ _______ _________ ___ ______ _______ __________ _______ ________ _________.
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