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Anaplerotic reactions are biochemical processes that replenish intermediates of metabolic pathways, particularly those involved in the citric acid cycle (TCA cycle or Krebs cycle). The citric acid cycle plays a central role in cellular energy production, where acetyl-CoA is oxidized to produce ATP, NADH, and FADH2. However, during various metabolic processes, some intermediates of the TCA cycle can be depleted. Anaplerotic reactions are crucial in maintaining the balance and flow of metabolites within the cycle, ensuring its continuous operation.

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