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The Boots synthesis of ibuprofen is a classic method for producing this nonsteroidal anti-inflammatory drug using principles that can be aligned with green chemistry by minimizing waste and avoiding hazardous reagents. The synthesis begins with isobutylbenzene as the starting material. The first step involves Friedel–Crafts acylation, where ____ _________ ________ ____ ____ ____ ______ ___ _______.
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