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In a case-control study, several methodological and design-related issues must be carefully considered to ensure the validity and reliability of findings. One major issue is selection bias, which occurs when cases and controls are not selected from the same population or when controls are not representative of the population that produced the cases. This bias can distort the true association between exposure and outcome. Another concern _________ ________ _________ _________ _________ _________ __________ ______ ______ _________.
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