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Meenu, admitted to the pediatric medical ward with anemia, mongoloid slant of eyes, and protruding maxilla, has been diagnosed with thalassemia, a hereditary hemoglobin disorder characterized by defective synthesis of globin chains. In children, beta-thalassemia major is the most severe form and usually presents within the first two years _________ __________ ___ _____ ___ __________ _________ __________ __________.
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