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Inhibitors of bacterial transcription act as effective antimicrobial agents by targeting the essential process of RNA synthesis in bacteria. Transcription is carried out by DNA-dependent RNA polymerase, which synthesizes RNA from a DNA template. Since gene expression is necessary for bacterial growth, metabolism, and replication, blocking transcription prevents the _________ _____ _________ _____ _________ _________ _________ _____ ___ _______.
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