Word Count : 397

---

Proteteins destined for the mitochondrial matrix are synthesized in the cytosol as precursor proteins with an N-terminal mitochondrial targeting sequence, typically rich in positively charged and hydroxylated amino acids forming an amphipathic alpha-helix. These precursor proteins remain unfolded in the cytosol due to the action of molecular chaperones such as Hsp70, which prevent premature folding and aggregation, ensuring they remain competent for translocation. The targeting sequence is recognized by receptors on the mitochondrial surface, primarily components of the translocase of the outer membrane (TOM) complex, including Tom20 and Tom22. Tom20 acts as the initial receptor binding to the hydrophobic ____ _______ ______ ________ ____ __________ ______.
_______ __________ _____ _________ ____ ______ ___ _______ __________.
________ ___ __________ ___ __________ _____ __________ __________ _______ _______ ________.
___ _______ ____ ___ ___ ______.
______ _____ _________ _____ ________ _______.
______ ___ _____ _________ _______ ________ ______ ____ __________.
_______ ____ _____ __________ __________ ________.
___ __________ ______ ____ __________ ___ ________ _______.
____ ____ _____ _______ _______ _________ _________ _____ _____ ______.
______ ________ ___ _________ _____ __________ ____ __________ ___ _________ ______ ____.
______ ___ _______ ____ ______.
_______ _____ _______ ___ __________.
__________ ____ _________ ___ _________ _____ _________ _______ _______ _______.
________ _____ _________ ________ ___ _____ _______ __________ _____ _______.
________ _____ ____ _____ _________.
__________ ______ ___ ______ ___.
___ ____ ________ ____ ______ ____ ________ _______ _________ _______ _______.
________ _________ ____ ____ _______ _______ ____ ______.
_________ __________ ______ ____ ______ _______ _______ _______ _________ ___ __________.
_____ ________ ________ ___ _________ ___ ________ _____ __________ _________ ________ _______.
________ __________ ___ ___ ___ __________ __________ ____ _______ ____ ______.
_______ _________ ______ ____ _________ ______.
_____ ____ __________ _________ ____ ____ __________ ____ _______ __________ _______ _________.
_________ _______ ________ __________ ______ ______ ______ _______.
_________ ___ _________ ___ _________.
________ ______ ________ _____ _____ _______ ________ _____ _________.
_______ _________ _________ ___ ____ __________.
__________ ___ _______ ____ _____.
____ __________ ____ ____ _____ _________ _________ __________.
_______ ________ __________ _______ _______ _____ _________ _________ _________ _________.
___ ________ ______ _______ ________ _________ ___ ________.
___ ________ ________ _____ ________.
______ ____ ____ _____ _______ _______ _____ ____ ________ _______.
____ _______ ____ _____ ________ _______ ______ _____ ______ _________ _______ __________.
__________ _____ ___ _________ ______ ______ _____ _________ ______.
_______ ________ ____ _______ _______ __________ ____ __________.
Get Full Answer on WhatsApp