In a parallel-line assay, total 18 guinea pigs, 4 guinea pigs each from 3 different breeds were selected and classified into 4 groups for each breed. Two groups were administered with two doses of the standard preparation and remaining two groups with two doses of the test preparation. The responses of these doses are recorded in the following table:
| Dose (Standard) | Dose (Test) | |||||
| Breed | 10 (in μL) | 15 (in μL) | 20 (in μL) | 5 (in μL) | 10 (in μL) | 15 (in μL) |
| 1 | 25 | 42 | 55 | 20 | 43 | 64 |
| 2 | 23 | 47 | 52 | 23 | 42 | 66 |
| 3 | 22 | 38 | 58 | 24 | 44 | 67 |
(i) Determine the dose-response regression models for both preparations.
(ii) Test whether the dose-response curves of both preparations are linear and parallel to each other or not.
(iii) Interpret whether the relative potency and its confidence interval can be computed or not.
The data on population and number of deaths for different age groups of Districts A and B in the year 2001 were collected in the following table:
| Age Group (Years) | District A | District B | ||
| Population | No. of Deaths | Population | No. of Deaths | |
| 0 - 5 | 55,300 | 385 | 51,165 | 805 |
| 5 –15 | 109,125 | 410 | 98,170 | 510 |
| 15-35 | 1,72,050 | 675 | 1,68,450 | 790 |
| 35-50 | 1,15,600 | 1625 | 1,40,625 | 990 |
| 50 & above | 2,65,775 | 3288 | 2,40,900 | 2485 |
Calculate standardised death rate by direct method, taking population of District A as the standard population.
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